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![]() Digital recruitment and analytics techniques are already in widespread use, as evidenced by several recent remote COVID-19 trials 19, 20, 21, 22, 23, but the incorporation of real-time digital health data collection in clinical trials has been limited. There are three key elements of a digital clinical trial: recruitment and retention, patient-reported and -collected health data, and digital analytics 18. Here, we describe our experience in the design and execution of this fully remote clinical trial, using digital technologies and infrastructure to provide real-time ascertainment of cardiovascular safety and risk in the evaluation of an investigational drug regimen for COVID-19. In this study, we utilized digital technologies that facilitated collaboration among scientists, implemented internet-based recruitment and enrollment, and leveraged rapid computer-assisted data analysis. Such remote trials may significantly improve access for patients who live in remote underserved places, work, have children, and/or lack transportation, which are common barriers to trial participation, and thus may help democratize clinical trials. ![]() Although hydroxychloroquine has been shown to be ineffective for the treatment of COVID-19 15, 16, 17, our experience with digital cardiac safety monitoring provides important proof of principle for a technology that can be applied broadly to facilitate more pragmatic, “site-less,” and increasingly digital clinical trials of the future. In light of concerns regarding potential cardiovascular toxicities related to hydroxychloroquine- and azithromycin-induced QT prolongation, this trial was designed to rigorously evaluate the cardiovascular safety of these regimens 9, 10, 11, 12, 13, 14. Therefore, we designed a randomized, placebo-equivalent trial to test two therapeutic regimens-hydroxychloroquine and hydroxychloroquine combined with azithromycin-for efficacy in reducing disease progression in ambulatory patients with COVID-19. Hydroxychloroquine and azithromycin, two widely available drugs, were of intense interest at the outset of the pandemic given their potential efficacy against SARS-CoV-2 based on in vitro and early observational data 6, 7, 8. In the context of a critical need to stem the morbidity and mortality of the SARS-CoV-2 pandemic, the development and testing of therapeutics has proceeded at an unprecedented pace 2, 3, 4, 5. Our report demonstrates that digital health technologies can be leveraged to conduct rigorous, safe, and entirely remote clinical trials.Ĭoronavirus disease 2019 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread to more than 194 million people and caused more than 4 million deaths globally as of July 2021 1. QTc prolongation meeting criteria for an adverse event occurred in 28 (12.1%) participants, with 2 occurring in the placebo group, 19 in the hydroxychloroquine group, and 7 in the hydroxychloroquine + azithromycin group. Adherence rates did not differ by age or sex assigned at birth and were high across all reported race and ethnicities. Mean daily adherence to the ECG protocol was 85.2% and was similar to the survey and mid-nasal swab elements of the study. Two hundred and thirty-one participants uploaded 3245 ECGs. ECG collection relied on a consumer device (KardiaMobile 6L, AliveCor Inc.) that recorded and transmitted six-lead ECGs via participants’ internet-enabled devices to a central core laboratory, which measured and reported QTc intervals that were then used to monitor safety. Self-collected vital signs (temperature, respiratory rate, heart rate, and oxygen saturation) and electrocardiographic (ECG) measurements were transmitted digitally to investigators while mid-nasal swabs for SARS-CoV-2 testing were shipped. All study activities were conducted remotely. In this report we describe the implementation of a novel exclusively remote randomized clinical trial ( NCT04354428) of hydroxychloroquine and azithromycin for the treatment of the SARS-CoV-2–mediated COVID-19 disease which included cardiovascular safety monitoring. The coronavirus disease 2019 (COVID-19) pandemic has challenged researchers performing clinical trials to develop innovative approaches to mitigate infectious risk while maintaining rigorous safety monitoring. Numerous players plunged into the battlefield, searching for weapons, equipment and materials. MaskGun is a passionate multiplayer real-time shooting battle game. Choose your hero, enter the arena, defeat other players, and take the first place in the game. The game has an explosive shooting scene. MaskGun, a punk-style competitive first-person shooter mobile game. Show appreciation for the game's popularity by subtly participating in the game. Make sure to vote and monitor the latest ranking updates to become a master in battles. Encourage your allies to work together for victory. We’re exceptionally intelligent and charismatic- traits that make us extremely attractive in this game. To attain victory, you need to demonstrate proficiency. Maskgun: An online FPS with competitive multiplayer where players must think creatively and be passionate in order to win. Without searching Google Play for a game to download, you're wasting time. However, improvements are in progress and it may one day be smooth with minimal memory requirements. At the moment, it takes up a lot of memory and has minor performance issues. When this app's functionality improves, it will become more efficient and reduce the amount of space needed on the phone. Fight with friends on maps such as Ryokan, GhostTown, or other multiplayer maps. Remember to fight hard, but don't forget your current health and energy to keep fighting. ![]() Maskgun: Multiplayer FPS - Online free shooting converges all into a mini-map. Select specific directions for greater results. Use the in-game map to find useful weapons or move in the correct direction. Working together for combat is an empowering experience that makes lasting memories for everyone involved. Search for allies through collaboration via ID. Surround yourself with people you can rely on and develop plans to overcome your enemy. Working together with friends against a common threat is a grand and wondrous thing. MaskGun: FPS Shooting Gun Game (169.38 MB)ĭownload Links: MaskGun: FPS Shooting Gun Game Mod APK 3.036 Fast Download (170.06 MB) MaskGun: FPS Shooting Gun Game Mod APK 3.036 Click here to learn how to use HappyMod to download and install all kinds of file types:xapk, bapk, apks. HappyMod is the best mod downloader for 100% working mods. You can download latest mod version or original version of MaskGun: FPS Shooting Gun Game 3.037 with HappyMod. ![]() The difference between mod version and original version is: Unlimited Money. MaskGun: FPS Shooting Gun Game Mod is a modified version of MaskGun: FPS Shooting Gun Game developed by June Gaming. ![]() The testing duration for the upcoming Steam CBT is set for Nov. 11/02 Steam CBT Operation (CBT Rewards) To submit your video head on over to the Community Videos section on the Bless Unleashed Steam Page: (You can read how to upload videos to steam here: ). ![]()
![]() In addition to that, if you are facing the Roblox Error Code 268, make sure to check out our comprehensive guide. If you have any questions, feel free to ask them in the comment section below. Make sure you do not miss out on these freebies to unlock your maximum potential. In conclusion, using the Roblox Rock Mine Simulator codes, players can obtain some rare freebies that help them become stronger and save time. The longer you play, the more rewards you obtain. Additionally, Roblox Rock Mine Simulator rewards players with freebies for simply logging in daily and playing the game. On the other hand, Pets and Rebirth permanently increase your stats. Power allows you to break through the rock faster. You can obtain power (currency), Rebirth, boosts, and Pets. Some walls only require a single click to break, while others can take up to 5 clicks. Finally, hit redeem and enjoy your free rewards!ĭeveloped by Rumble Studios, Roblox Rock Mine Simulator is an idle simulator game where your main goal is to get strong enough to be able to take down massive rock walls.Next, copy a code from the list above and paste it into the gray box that says “ Code Here“.After that, click on the blue Twitter icon located on the middle-right side of the screen.Make sure to follow the steps carefully to avoid any confusion. Fortunately, the process of claiming codes in the Roblox Rock Mine Simulator is quite easy. How To Redeem Roblox Rock Mine Simulator Codes? Redeeming Rock Mine Simulator Codes 2023 Once you have successfully acquired the codes, the next step is to redeem them to attain your freebies. Redeem the code for a 3x win boost (5 minutes). However, these codes do not have an expiration date, therefore, make sure to redeem them before they are expired.Ĭlaim the code to unlock the Desert Zone. Additionally, all the codes have been fully tested and are functional at the time of writing this guide. The list below contains all the active codes for Roblox Rock Mine Simulator. ![]() To stay up to date with the latest codes, players are advised to bookmark this page and come back after every few weeks.Players can customize their game settings with these codes and be rewarded for completing specific objectives. To make the game even more enjoyable, a variety of codes are available for Desert Zone Wars codes. If you are facing any technical difficulties while redeeming your codes, make sure to check out Ultimate Code Guide to fix all code-related issues. The goal is to survive the harsh desert environment while fighting off enemy players and using the domain to your advantage.In order to find additional codes, players can join the Official Discord Server for Craz圜orrs Games and follow the developer’s official Twitter page as well.To redeem your Roblox Rock Mine Simulator codes, simply click on the blue Twitter icon, input your code in the gray box, and hit redeem.HYPE is currently one of the active codes for the Roblox Rock Mine Simulator.You can use Power, Rebirth, and Boost to break through rocks faster and increase your stats both permanently and temporarily.Roblox Rock Mine Simulator Codes can be redeemed for Rebirth, Power, Boosts, and unlock zones. A popup will ask if you would like to create a new account or use an existing one. On the power menu that appears, select “Multiplayer” and then “Add Player”.Ĥ. Once your game has loaded, press the Xbox button on your controller.ģ. Start by loading the game you want to play.Ģ. Playing split screen on your Xbox One is actually quite simple! Here’s how to do it:ġ. How do I play split screen on my Xbox One? Include any error codes displayed on screen when you try to play split screen to help with troubleshooting. You should contact Xbox support for further assistance. If these steps do not fix the issue, a console malfunction could be to blame. Once there, select ‘Reset Data’ and this will delete user created content and reset any settings to their factory defaults. You can do this by going to the game’s main menu, then navigating to the Options tab. If the console settings are enabled and up-to-date, you should then try resetting the game data to see if this resolves the issue. ![]() You should also check that the console is up-to-date with the latest system update. If you have multiple accounts signed in, only the primary account will be able to access the local co-op mode. The first step is to check your console settings to ensure that local co-op is enabled. ![]() Troubleshooting can help determine the cause of the issue. It could be due to a bug with the game, an issue with your system’s console settings, or a glitch in the way the game was developed. Split screen may not be working on your Modern Warfare Xbox because of several different issues. Do let us know your views on these and how did you like the websites. So, this was our list of 5 Best Free Ringtone Websites to download best ringtones for your iPhone and Android devices. ITUNEMACHINE is an awesome free ringtones website that everyone looking for ringtones should try. Also, the download button is available right below the name of the ringtone and in just two clicks, you will have your desired ringtone on your device ready to create an impression. Like the previously mentioned website, you can click on the play button to first listen to the ringtone before downloading it. The welcome page greets you with a few very popular ringtones with the information about the number of times they have been downloaded and the year in which they were added. ![]() The site follows minimalism and you will appreciate their minimum ads policy. It offers unlimited ringtones and alert tones of HD quality. ITUNEMACHINE is another sleek website offering free ringtones for Android as well as iPhone. Audiko ringtones is another free ringtone app for iPhone with immaculate features. To download the ringtone, all you have to do is click on the free ringtone and click on download to simply download it to your device. Like all other websites on the list, you can play the ringtone before downloading it to use for your mobile phone. Once you’ve selected a ringtone you like, click the Android or iPhone button and the ringtone for the specific format you need. You’ll find a few different variations of the ringtones to choose from. It also gives the option to search for your desired ringtone if you have pre-decided on the ringtone you want to download. You can find your favorite ringtones using the search function on the top, and then preview the ringtone on its page. ![]() You can look for a suitable ringtone by browsing different categories as well as by sorting the ringtones by popularity and the time when they were added. The interface of MyTinyPhone website is the best we have seen on the list. ![]() MyTinyPhone boasts over 5 lac free ringtones for your mobile phone. Like most other websites offering free ringtones, it also offers free wallpapers to download for your phone. You can then download the ringtone for Android as well as iPhone. You can try and play the ringtone before downloading to check if it suits you. Mobile Guides How to make ringtones for an iPhone By Jesse Hollington and Jackie Dove J7:00AM With texting now more common than calling for many people, and many now using VoiP. The website’s welcome page showcases few of the randomly organized ringtones based on their popularity. The interface of the website is pretty simple and decent. Lots of songs with a collection of the best and most popular ringtones for iPhone. You can also listen to the ringtone before downloading it. Do you want new popular ringtones or ringtone remix Ringtones for iPhone is best app for you. You can view the popularity of these ringtones and tags attached to it, its ratings, etc. It has ringtones for Android as well as for iPhones. Like Tones7, CellBeat lets you surf through dozens of categories of downloadable free ringtones. Also, feel free to leave comments suggesting what you'd like to see in the next update.CellBeat is the third free ringtones website on our list. ![]() We value your feedback, so if you’re enjoying the app, please leave a rating and a review. Sounds used in this app are under Public Domain or Creative Commons license, credited inside the app. Tons of stunning latest ringtones for iPhone. Make your phone one-of-a-kind with unique cell phone ringtones, the best music ringtones & high-quality popular sounds and show off your style! It's really easy with the Popular ringtones app. Use your own music library to create your ringtone This amazing app lets you create ringtones by adding customizations to your heart’s content. Save the ringtone on your iPhone and setup it as contact ringtone / alarm sound / sms sound Ringtones for iPhone (music) Editor’s Choice Want to dance to your favorite lyrics every time your iPhone rings Well, then, the Ringtones for iPhone is here at your service. Easy install, you don't need a computer to install the ringtone on your phone Join the family of 20+ million satisfied users in a minute! Don't pay again to customize your iPhone ringtone, use the best free app.īored by the default ringtones you have on your iPhone? Our Best Ringtones for iPhone app will help you to get your own style ! Download it now and Make your iPhone unique in a minute.Įxplore tons of best ringtones for iPhone and choose among 22+ different categories: the most popular music ringtones, classical ringtones, jazz, pop, electro, disco, romantic, reggae, rock or even latino and country music ringtones! Discover high-quality top phone and latest free ringtones in one single app. Create your own ringtones from your music library or browse through our huge music catalog. I had some pretty big chunks in the first batch (as pictured below), it was better with smaller pieces in my opinion. The only thing I did differently the second time around was the crush the peppermint up a little more. The amount of vanilla makes a huge difference in the flavor. The mix-ins (peppermint candies as opposed to chocolate) and the amount of vanilla that’s added to the mix. Pink peppermint ice cream isn’t much different than mint chocolate chip ice cream. I found a couple of recipes on the net, but ended up developing my own using the sweetened condensed milk, cream and milk formula I’ve used in a couple other recipes. I’ve made it three times, and each time it’s been polished off by the family. I didn’t want to wait for Christmas to have it, so I made my own. I buy it throughout the year when I can find it, but it’s more prominent in stores at Christmastime. Once combined, turn mixer to medium speed and beat for another minute or so until a smooth, thick paste (like the inside of a peppermint patty) is formed.I love pink peppermint ice cream. Make sure to add the ingredients in that order for proper mixing. Let cool to room temperature while you prepare the tart filling.įor filling, in the bowl of a standing mixer fitted with the paddle attachment, cream the sugar, butter, extracts, schnapps (if using) and heavy cream. Remove the foil, gently pushing down any part of the crust that has puffed, and bake for about 5 minutes more. Partially bake it (no need for pie weights) until golden in color, 30 to 35 minutes. Meanwhile, preheat the oven to 375 degrees.īutter the shiny side of a piece of aluminum foil and fit it tightly over the tart shell. Freeze the tart shell for about 30 minutes. Roll out the dough and pat it into a greased and floured 11-inch tart pan. ![]() Add the egg yolk and pulse until the dough begins to form together. Add the cubed butter and pulse to incorporate until the mixture resembles cornmeal and peas. Particularly during the wintertime, the fragrant herbs are a nice touch of green you can keep on your windowsill and use in holiday cooking and baking.ĩ tablespoons unsalted butter, cold and cubedĢ 1/2 tablespoons unsalted butter, softenedĢ teaspoons peppermint schnapps (optional)Ĩ ounces 60-70 percent cacao chocolate, chopped (or use chocolate chips)Ģ candy canes or peppermint candies, crushed (optional)įor the crust, combine flour, sugar and salt in the bowl of a food processor and pulse to combine. Richard doesn't farm mint anymore - larger commercial farms in the Northwest and Asia squeezed out small Midwestern mint farmers a few years ago - but as a reminder of that childhood memory, I like to grow mint plants at home. One inhalation of the mint oil completely cleared out our sinuses and must have prevented us from catching the cold through the winter - a special Indiana farm remedy. Then we'd pile in the farm truck and head down the dirt roads to the still, the mint essence becoming stronger and stronger until we were finally lifted over the boiling vat for the most intense sensory experience. I have memories of driving out to the farm when Richard was distilling that season's crop into oil, catching whiffs of the mint on the air miles before we arrived. The fragrant herbs are a nice touch of green you can keep on your windowsill and use in holiday cooking and baking. |
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